Science

Peer-reviewed publications

1. Fortelny N, Farlik M, Fife V, Gorki A, Lassnig C, Maurer B, Meissl K, Dolezal M, Boccuni L, Geetha ARSJ, Akagha MJ, Karjalainen A, Shoebridge S, Farhat A, Mann U, Jain R, Tikoo S, Zila N, Esser-Skala W, Krausgruber T, Sitnik K, Penz T, Hladik A, Suske T, Zahalka S, Senekowitsch M, Barreca D, Halbritter F, Macho-Maschler S, Weninger W, Neubauer HA, Moriggl R, Knapp S, Sexl V, Strobl B, Decker T, Müller M, Bock C
   JAK-STAT signaling maintains homeostasis in T cells and macrophages
   Nat Immunol xxx (xxx), xxx (2024)
2. Esser-Skala W, Fortelny N
   Reliable interpretability of biology-inspired deep neural networks
   NPJ Syst Biol Appl 9 (1), 50 (2023)
3. Fetahu IS, Esser-Skala W, Dnyansagar R, Sindelar S, Rifatbegovic F, Bileck A, Skos L, Bozsaky E, Lazic D, Shaw L, Tötzl M, Tarlungeanu D, Bernkopf M, Rados M, Weninger W, Tomazou EM, Bock C, Gerner C, Ladenstein R, Farlik M, Fortelny N, Taschner-Mandl S
   Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis
   Nat Commun 14 (1), 3620 (2023)
4. Marco FD, Blöchl C, Esser-Skala W, Schäpertöns V, Zhang T, Wuhrer M, Sandra K, Wohlschlager T, Huber CG
   Glycoproteomics of a single protein: Revealing tens of thousands of Myozyme glycoforms by hybrid HPLC-MS approaches
   Mol Cell Proteomics 22 (9), 100622 (2023)
5. Esser-Skala W, Fortelny N
   The protease web
   Chapter 11 in: Zelanis A (ed.). Proteolytic signaling in health and disease. Elsevier (2022). 229–250
6. Böttinger K, Esser-Skala W, Segl M, Herwig C, Huber CG
   At-line quantitative profiling of monoclonal antibody products during bioprocessing using HPLC-MS
   Anal Chim Acta 1207 , 339813 (2022)
7. Di Marco F, Berger T, Esser-Skala W, Rapp E, Regl C, Huber CG
   Simultaneous monitoring of monoclonal antibody variants by strong cation-exchange chromatography hyphenated to mass spectrometry to assess quality attributes of rituximab-based biotherapeutics
   Int J Mol Sci 22 (16), 9072 (2021)
8. Lebede M, Di Marco F, Esser-Skala W, Hennig R, Wohlschlager T, Huber CG
   Exploring the chemical space of protein glycosylation in noncovalent protein complexes: An expedition along different structural levels of human chorionic gonadotropin by employing mass spectrometry
   Anal Chem 93 (30), 10424–10434 (2021)
9. Esser-Skala W, Segl M, Wohlschlager T, Reisinger V, Holzmann J, Huber CG
   Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins
   Anal Bioanal Chem 412 (24), 6583–6593 (2020)
10. Esser-Skala W, Wohlschlager T, Huber CG
    In search for the needle in the Mariana Trench: host cell proteins and the problem of dynamic range
    LC-GC Europe 33 (S10), 13–19 (2020)
11. Esser-Skala W, Wohlschlager T, Regl C, Huber CG
    A simple strategy to eliminate hexosylation bias in the relative quantification of N-glycosylation in biopharmaceuticals
    Angew Chem Int Ed Eng 59 (37), 16225–16232 (2020)
12. Esser-Skala W, Wohlschlager T, Regl C, Huber CG
    Eine einfache Strategie zur Korrektur des Fehlers aufgrund von Hexosylierung bei relativer Quantifizierung der N‐Glykosylierungsvarianten von Biopharmazeutika
    Angew Chem 132 (37), 16359–16367 (2020)
13. Regl C, Wohlschlager T, Esser-Skala W, Wagner I, Samonig M, Holzmann J, Huber CG
    Dilute-and-shoot analysis of therapeutic monoclonal antibody variants in fermentation broth: a method capability study
    mAbs 11 (3), 569–582 (2019)
14. Skala W, Wohlschlager T, Senn S, Huber GE, Huber CG
    MoFi: A software tool for annotating glycoprotein mass spectra by integrating hybrid data from the intact protein and glycopeptide level
    Anal Chem 90 (9), 5728–5736 (2018)
15. Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P
    Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin
    Sci Rep 8 (1), 10705 (2018)
16. Wohlschlager T, Scheffler K, Forstenlehner IC, Skala W, Senn S, Damoc E, Holzmann J, Huber CG
    Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals
    Nat Commun 9 (1), 1713 (2018)
17. Guo S, Skala W, Magdolen V, Briza P, Biniossek ML, Schilling O, Kellermann J, Brandstetter H, Goettig P
    A single glycan at the 99-loop of human kallikrein-related peptidase 2 regulates activation and enzymatic activity
    J Biol Chem 291 (2), 593–604 (2016)
18. Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P
    Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity
    J Biol Chem 289 (49), 34267–34283 (2014)
19. Guo S, Skala W, Magdolen V, Brandstetter H, Goettig P
    Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity.
    Biol Chem 395 (9), 959–976 (2014)
20. Skala W, Goettig P, Brandstetter H
    Do-it-yourself histidine-tagged bovine enterokinase: a handy member of the protein engineer's toolbox
    J Biotechnol 168 (4), 421–425 (2013)

Theses

1. Organisation des Austrian Proteomics and Metabolomics Research Symposium 2019
   Final thesis (supervisor: Sabine Reithofer-Reinhardt), SMBS, 2019
2. Die Lösung des restringierten Steinerbaum-Problems mittels lokaler Suchverfahren
   Bachelor thesis (supervisor: Friedhelm Kulmann), FernUniversität in Hagen, 2015
3. Biochemical and structural characterization of human kallikrein-related peptidase 2 activated by do-it-yourself histidine-tagged bovine enterokinase
   PhD thesis (supervisors: Hans Brandstetter and Peter Goettig), University of Salzburg, 2014
4. Putative macaque and orangutan homologues of tripeptidyl-peptidase II underline the importance of its C-terminal part for enzymatic activity and proper oligomerization
   Master thesis (supervisor: Hans Brandstetter), University of Salzburg, 2010
5. Crystallization: From art to science
   Bachelor thesis (supervisor: Hans Brandstetter), University of Salzburg, 2008
6. Determining the current-voltage characteristic: An electrophysiological study on Aquaporin-6
   Bachelor thesis (supervisor: Peter Pohl), Johannes Kepler University Linz, 2007

LaTeX packages

• pgfgantt v5.0 (2018)
• pgfmolbio v0.21 (2013)
• cpssp v1.0 (2009)

Trivia

I also wrote about 2300 pages of scripts for approximately 20 courses I attended during my academic studies. These texts constitute six formidable volumes of Collected Works that rest on my bedroom shelf.